Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery
نویسندگان
چکیده
Abstract Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family proteins (CDK) and critical for cancer development. Years study into CDK12 have generated much information regarding intricacy its function mechanism as well inhibitors against it oncological research. However, there remains lack understanding role in carcinogenesis prevention. An exhaustive comprehension will highly stimulate development new strategies treating preventing cancer. Here, we review literature CDK12, with focus on function, signaling, how to use target discovery novel drugs prevention therapy.
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2021
ISSN: ['1538-7445', '0008-5472']
DOI: https://doi.org/10.1158/0008-5472.can-20-2245